Jacob D. Ramsey

This paper introduces synthetic polymer-based lipid alternatives for lipid nanoparticles, showing they can replace standard lipids while maintaining transfection activity.

This study develops PEG-free poly(2-oxazoline) lipids for LNPs, showing improved transfection, reduced liver accumulation, and enhanced immune tissue targeting in vivo.

This paper develops a nanoparticle formulation of vismodegib that improves its efficacy for medulloblastoma treatment by enhancing CNS pharmacokinetics and reducing systemic toxicity.