Mutation accumulation underpins evolution of lifespan extension by dietary restriction
Sara D. Irish, A Jordan Kimberley, Simone Immler, Jacob A. Moorad, Alexei A. Maklakov
This study shows that dietary restriction extends lifespan in C. elegans by suppressing fertility, not through adaptive hypotheses, and suggests mutation accumulation drives this evolutionary effect.
bioRxiv · Jun 18, 2025 · PreprintEvolutionary Biology