Pharmacological inhibition of 11βhydroxysteroid dehydrogenase type 1 after myocardial infarction targets extracellular matrix processing and preserves cardiac function in a translational mini-pig model
Sara Al Disi, Raimondo Ascione, Shazia Khan, TW Johnson, Eva C. Sammut, Vito Domenico Bruno, Daniel Baz-Lopez, Carol-Ann James, Joanna P. Simpson, Natalie Z M Homer, MIchael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, B. S. Walker, , Gillian A. Gray
This study shows that inhibiting 11βHSD1 after myocardial infarction preserves cardiac function and prevents adverse remodelling in a mini-pig model.
British Journal of Pharmacology · Dec 28, 2025Peer-reviewedPharmacology & Toxicology