An adaptive pre-DNA-damage-response protects genome integrity
S. Ragu, G. Matos-Rodrigues, N. Droin, A. Barascu, S. Caillat, G. Zarkovic, C. Siberchicot, E. Dardillac, C. Gelot, J. P. Radicella, A. A. Ishchenko, J.-L. Ravanat, E. Solary, B. S. Lopez
The paper identifies a pre-DDR response in human fibroblasts that protects genome integrity without arresting cell cycle progression by managing ROS levels below a stress threshold.
bioRxiv · May 13, 2020 · PreprintCell Biology