Major role of S-glycoprotein in providing immunogenicity and protective immunity in mRNA lipid nanoparticle vaccines based on SARS-CoV-2 structural proteins
E. N. Bykonia, D. A. Kleymenov, V. A. Gushchin, A. E. Sinyavin, E. P. Mazunina, N. Kuznetsova, S. R. Kozlova, A. N. Zolotar, E. V. Shidlovskaya, E. V. Usachev, A. A. Pochtovyi, D. D. Kustova, I. A. Ivanov, S. E. Dmitriev, R. A. Ivanov, , A. L. Gintsburg
This study evaluates mRNA-LNP vaccines encoding SARS-CoV-2 structural proteins, finding that the S protein enhances immune responses to N protein, while M protein has low immunogenicity.
bioRxiv · Dec 30, 2023Immunology