The IgE production is initially induced in subcutaneous fat and depends on extrafollicular B cells
D. B. Chudakov, G. V. Fattakhova, M. V. Konovalova, D. S. Tsaregorotseva, M. A. Shevchenko, O. D. Kotsareva, A. A. Sergeev, E. V. Svirshchevskaya
This study shows that subcutaneous fat-associated B-cells drive early IgE production through extrafollicular pathways, distinct from lymph nodes and visceral fat.
bioRxiv · Aug 18, 2021 · PreprintImmunology