Closely related Cryptococcus neoformans strains possess differential virulence both in humans and the mouse inhalation model
L. Mukaremera, T. R. McDonald, J. N. Nielsen, A. Akampulira, C. Schutz, K. Tazeera, C. Muzoora, G. A. Meintjes, D. B. Meya, D. Boulware, K. Nielsen
This study shows that closely related Cryptococcus neoformans strains have different virulence in humans and mice, with mortality linked to antigen levels, fungal burden, and clearance, not genotype or single virulence factors.
bioRxiv · Jan 18, 2019Microbiology