Molecular Strategy for Blocking Isopeptide Bond Formation in Nascent Pilin Proteins
J. A. Rivas-Pardo, R. Tapia-Rojo, C. L. Badilla, A. Alonso Caballero, J. M. Fernandez
This paper designs a peptide that blocks isopeptide bond formation in pilin proteins, reducing mechanical stability and demonstrating a potential strategy for anti-adhesive antibiotics.
bioRxiv · Aug 27, 2018Biophysics