A. Alonso-Caballero

Mechanical forces and ligand-binding modulate Pseudomonas aeruginosa PilY1 mechanosensitive protein

This study investigates how mechanical forces and ligand binding affect the conformational dynamics of PilY1's C-terminal domain in Pseudomonas aeruginosa.

Identical Sequences, Different Behaviors: ProteinDiversity Captured at the Single-Molecule Level

This paper introduces a magnetic tweezers technique to measure single-molecule protein folding dynamics over days, revealing molecular diversity through force response and folding kinetics.

Magnetic tweezers meets AFM: ultra-stable protein dynamics across the force spectrum

This paper develops a magnetic tweezers method capable of applying high forces with stability and resolution, demonstrating its use on the mechanostable protein FimA.

Talin Folding as the Tuning Fork of Cellular Mechanotransduction

This study shows talin acts as a mechanical bandpass filter, filtering out noise and detecting periodic force signals through its folding dynamics.

Direct Observation of a Coil-to-Helix Contraction Triggered by Vinculin Binding to Talin

The paper uses magnetic tweezers to observe vinculin-induced contraction of unfolded talin under force, revealing a force-dependent mechanism regulating mechanotransduction in focal adhesions.

Protein folding modulates the adhesion strategy of Gram positive pathogens

This study shows how protein folding modulates the adhesion strategy of Gram positive pathogens by switching between reversible and irreversible bonding under different mechanical forces.