A competitive activity-based protein profiling platform yields cell wall synthesis inhibitors active against replicating and non-replicating Mycobacterium tuberculosis
M. Li, H. V. Patel, A. B. Cognetta, T. C. Smith, B. B. Aldridge, I. Mallick, J.-F. Cavalier, T. C. Smith, B. F. Cravatt, J. C. Seeliger
This study uses ABPP to identify cell wall synthesis inhibitors targeting Mycobacterium tuberculosis, showing that active compounds inhibit serine hydrolases involved in cell wall and lipid metabolism.
bioRxiv · Apr 16, 2021Microbiology