The Acute Myeloid Leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme
A. B. Norvil, L. AlAbdi, B. Liu, N. E. Forstoffer, A. R. Michie, T. Chen, H. Gowher
The paper shows that the DNMT3A Arg882His variant in AML acquires DNMT3B-like substrate preference, potentially contributing to its oncogenic effect.
bioRxiv · Jul 31, 2019Biochemistry