The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS
M. N. Hurst, C. J. Beebout, A. Hollingsworth, K. R. Guckes, A. B. Purcell, T. Bermudez, D. Williams, M. S. Trent, M. Hadjifrangiskou
This paper shows QseB enhances polymyxin B tolerance in UPEC by modifying LPS and regulating glutamate metabolism, revealing a new mechanism of antibiotic resistance.
bioRxiv · Jan 10, 2023Microbiology