Author

M. Hadjifrangiskou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Organism:E. coli· 7 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:metabolomics· 2 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

C. J. Beebout· 5 shared J. R. Brannon· 4 shared S. Reasoner· 4 shared M. A. Wiebe· 3 shared T. Bermudez· 3 shared A. Bamidele· 2 shared G. H. Morales· 2 shared K. R. Guckes· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersMicrobiology

C. J. Beebout

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Author profile →

7 papers

Recent·Most cited

Drug Resistance without a cost? Common and uncommon routes to fosfomycin resistance in Uropathogenic Escherichia coli

T. Bermudez, J. R. Brannon, N. Dudipala, S. Reasoner, G. H. Morales, M. A. Wiebe, M. Cecala, C. J. Beebout, O. Amir, M. Hadjifrangiskou

This study identifies multiple routes to fosfomycin resistance in uropathogenic E. coli that do not impair pathogenesis, suggesting a need to revise AST guidelines.

bioRxiv · Jun 20, 2023Microbiology

Mapping Niche-specific Two-Component System Requirements in Uropathogenic Escherichia coli

J. R. Brannon, S. Reasoner, T. Bermudez, T. L. Dunigan, M. A. Wiebe, C. J. Beebout, T. L. Ross, A. Bamidele, M. Hadjifrangiskou

This study identifies niche-specific two-component systems (TCSs) in uropathogenic Escherichia coli (UPEC) critical for colonization of the bladder, kidneys, and vagina during infection.

bioRxiv · May 23, 2023Microbiology

The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS

M. N. Hurst, C. J. Beebout, A. Hollingsworth, K. R. Guckes, A. B. Purcell, T. Bermudez, D. Williams, M. S. Trent, M. Hadjifrangiskou

This paper shows QseB enhances polymyxin B tolerance in UPEC by modifying LPS and regulating glutamate metabolism, revealing a new mechanism of antibiotic resistance.

bioRxiv · Jan 10, 2023Microbiology

Serine Deamination as a New Acid Resistance Mechanism in Escherichia coli

M. A. Wiebe, J. R. Brannon, B. D. Steiner, A. Bamidele, A. C. Schrimpe-Rutledge, S. G. Codreanu, S. D. Sherrod, J. McLean, M. Hadjifrangiskou

This study identifies L-serine deamination as a novel acid resistance mechanism in E. coli, where serine is converted to pyruvate and ammonia to enhance acid tolerance during stationary phase.

bioRxiv · May 5, 2022 · PreprintMicrobiology

Redox-mediated inactivation of the transcriptional repressor C3600 makes uropathogenic Escherichia coli exquisitely resistant to reactive chlorine species

S. Sultana, K. LeDoux, M. E. Crompton, O. Jankiewicz, G. H. Morales, C. Johnson, E. Horbach, K. P. Hoffmann, P. KR, R. Shah, G. M. Anderson, N. T. Mortimer, J. E. Schmitz, M. Hadjifrangiskou, A. Foti, J.-U. Dahl

This study identifies a redox-mediated mechanism in UPEC that enhances resistance to HOCl by inactivating the transcriptional repressor C3600 through disulfide bond formation.

bioRxiv · Aug 31, 2021 · PreprintMicrobiology

A Bacterial Signaling Network Controls Antibiotic Resistance by Regulating Anaplerosis of 2-oxoglutarate

M. N. Hurst, C. J. Beebout, R. Mersfelder, A. N. Hollingsworth, K. R. Guckes, T. A. Bermudez, K. A. Floyd, S. Reasoner, D. C. Williams, M. Hadjifrangiskou

This study identifies a bacterial signaling network that regulates 2-oxoglutarate anaplerosis to enhance antibiotic resistance in Escherichia coli.

bioRxiv · Oct 22, 2020 · PreprintMicrobiology

Respiratory heterogeneity shapes biofilm formation and host colonization in uropathogenic Escherichia coli

C. J. Beebout, A. R. Eberly, S. H. werby, S. Reasoner, J. R. Brannon, S. De, M. J. Fitzgerald, M. M. Huggins, D. B. Clayton, L. Cegelski, M. Hadjifrangiskou

This study shows that respiratory heterogeneity in uropathogenic E. coli influences biofilm formation and host colonization through differential expression of cytochrome oxidases.

bioRxiv · Nov 2, 2018Microbiology