Author

C. J. Beebout

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Organism:E. coli· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

M. Hadjifrangiskou· 5 shared J. R. Brannon· 4 shared S. Reasoner· 4 shared T. Bermudez· 3 shared K. R. Guckes· 2 shared M. A. Wiebe· 2 shared M. N. Hurst· 2 shared A. B. Purcell· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersMicrobiology

M. Hadjifrangiskou

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6 papers

Recent·Most cited

Drug Resistance without a cost? Common and uncommon routes to fosfomycin resistance in Uropathogenic Escherichia coli

T. Bermudez, J. R. Brannon, N. Dudipala, S. Reasoner, G. H. Morales, M. A. Wiebe, M. Cecala, C. J. Beebout, O. Amir, M. Hadjifrangiskou

This study identifies multiple routes to fosfomycin resistance in uropathogenic E. coli that do not impair pathogenesis, suggesting a need to revise AST guidelines.

bioRxiv · Jun 20, 2023Microbiology

Mapping Niche-specific Two-Component System Requirements in Uropathogenic Escherichia coli

J. R. Brannon, S. Reasoner, T. Bermudez, T. L. Dunigan, M. A. Wiebe, C. J. Beebout, T. L. Ross, A. Bamidele, M. Hadjifrangiskou

This study identifies niche-specific two-component systems (TCSs) in uropathogenic Escherichia coli (UPEC) critical for colonization of the bladder, kidneys, and vagina during infection.

bioRxiv · May 23, 2023Microbiology

The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS

M. N. Hurst, C. J. Beebout, A. Hollingsworth, K. R. Guckes, A. B. Purcell, T. Bermudez, D. Williams, M. S. Trent, M. Hadjifrangiskou

This paper shows QseB enhances polymyxin B tolerance in UPEC by modifying LPS and regulating glutamate metabolism, revealing a new mechanism of antibiotic resistance.

bioRxiv · Jan 10, 2023Microbiology

Balanced Input from the tRNA Prenyltransferase MiaA Controls the Stress Resistance and Virulence Potential of Extraintestinal Pathogenic Escherichia coli

M. G. Blango, B. A. Fleming, W. M. Kincannon, A. Tran, A. J. Lewis, C. W. Russell, Q. Zhou, L. M. Baird, J. R. Brannon, C. J. Beebout, V. Bandarian, M. Hadjifraniskou, M. T. Howard, M. A. Mulvey

This study shows that MiaA, but not MiaB, is critical for the fitness and virulence of ExPEC, and that stress can alter MiaA expression to affect translation and proteome composition.

bioRxiv · Feb 2, 2021 · PreprintMicrobiology

A Bacterial Signaling Network Controls Antibiotic Resistance by Regulating Anaplerosis of 2-oxoglutarate

M. N. Hurst, C. J. Beebout, R. Mersfelder, A. N. Hollingsworth, K. R. Guckes, T. A. Bermudez, K. A. Floyd, S. Reasoner, D. C. Williams, M. Hadjifrangiskou

This study identifies a bacterial signaling network that regulates 2-oxoglutarate anaplerosis to enhance antibiotic resistance in Escherichia coli.

bioRxiv · Oct 22, 2020 · PreprintMicrobiology

Respiratory heterogeneity shapes biofilm formation and host colonization in uropathogenic Escherichia coli

C. J. Beebout, A. R. Eberly, S. H. werby, S. Reasoner, J. R. Brannon, S. De, M. J. Fitzgerald, M. M. Huggins, D. B. Clayton, L. Cegelski, M. Hadjifrangiskou

This study shows that respiratory heterogeneity in uropathogenic E. coli influences biofilm formation and host colonization through differential expression of cytochrome oxidases.

bioRxiv · Nov 2, 2018Microbiology