PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
S. U. Jain, T. J. Do, P. J. Lund, A. Q. Rashoff, M. Cieslik, K. L. Diehl, A. Bajic, N. Juretic, S. Deshmukh, S. Venneti, T. W. Muir, B. A. Garcia, N. Jabado, P. W. Lewis
This study identifies EZHIP as a PRC2 inhibitor in PFA ependymomas that mimics the H3 K27M oncohistone by disrupting PRC2 activity and H3K27me3 levels.
bioRxiv · Mar 22, 2019Cancer Biology