Author

T. W. Muir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cancer Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Assay:ChIP-seq· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. Zhang· 2 shared S. P. Bodine· 2 shared A. Athreya· 1 shared A. Bajic· 1 shared A. J. Burton· 1 shared A. Q. Rashoff· 1 shared A. Zhao· 1 shared B. A. Garcia· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

B. Zhang

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Author profile →

8 papers

Recent·Most cited

Electrostatic encoding of genome organization principles within single native nucleosomes

S. Park, A. Athreya, G. Carrizo, N. Benning, M. Mitchener, N. Bhanu, B. Garcia, B. Zhang, T. W. Muir, E. Pearce, T. Ha

This study shows that single nucleosomes encode A/B compartment information through biophysical properties, specifically condensability, which correlates with gene expression and is electrostatic in nature.

bioRxiv · Dec 8, 2023Biophysics

Distinct microcolony morphologies promote flow-dependent bacterial colonization

K. M. Hallinen, S. P. Bodine, H. A. Stone, T. W. Muir, N. S. Wingreen, Z. Gitai

The paper shows that bacterial species use distinct microcolony morphologies to colonize surfaces under high fluid flow, with S. aureus relying on signaling molecules and E. faecalis on mechanical forces.

bioRxiv · Nov 22, 2023 · PreprintMicrobiology

Distinct phases of cellular signaling revealed by time-resolved protein synthesis

G. Lee, T. W. Muir

This study uses a protein trans-splicing technology to reveal distinct phases of signaling in cancer-related proteins like BCR/ABL and DNAJB1/PRKACA.

bioRxiv · Jul 10, 2023Biochemistry

A genetically encoded photo-proximity labeling approach for mapping protein territories

N. Hananya, X. Ye, S. Koren, T. W. Muir

This paper introduces a photo-proximity labeling system using visible light to capture protein interactomes with high temporal resolution and correlates it with imaging and proteomics.

bioRxiv · Jul 30, 2022 · PreprintBiochemistry

Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis

A. Zhao, S. P. Bodine, Q. Xie, B. Wang, G. Ram, R. P. Novick, T. W. Muir

This study identifies MroQ as the second protease in the S. aureus agr quorum sensing pathway, showing its role in AIP biosynthesis and revealing molecular features guiding its cleavage activity.

bioRxiv · Dec 29, 2021Microbiology

Tracking chromatin state changes using μMap photo-proximity labeling

C. P. Seath, A. J. Burton, D. W. C. MacMillan, T. W. Muir

This paper introduces Chroma-Map, a method to track chromatin state changes by using photo-proximity labeling to analyze protein interactions in the nucleus, showing its application in studying cancer mutations and drug effects.

bioRxiv · Sep 28, 2021 · PreprintCancer Biology

PRC2 bridges non-adjacent nucleosomes to establish heterochromatin

R. Leicher, E. J. Ge, X. Lin, M. J. Reynolds, T. Walz, B. Zhang, T. W. Muir, S. Liu

This study investigates how PRC2 interacts with chromatin using single-molecule force spectroscopy and simulations, revealing new binding configurations and their regulation.

bioRxiv · Oct 7, 2019Biophysics

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism

S. U. Jain, T. J. Do, P. J. Lund, A. Q. Rashoff, M. Cieslik, K. L. Diehl, A. Bajic, N. Juretic, S. Deshmukh, S. Venneti, T. W. Muir, B. A. Garcia, N. Jabado, P. W. Lewis

This study identifies EZHIP as a PRC2 inhibitor in PFA ependymomas that mimics the H3 K27M oncohistone by disrupting PRC2 activity and H3K27me3 levels.

Nature Communications · May 13, 2019Peer-reviewedCancer Biology