The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Negatively Regulating Th17 Response
G. Gupta, P. Jia, R. Sharma, R. Zayats, S. M. Viana, L. Shan, Z. Mou, V. S. Boaventura, A. Barral, T. T. Murooka, A. Soussi-Gounni, C. I. de Oliveira, J. E. Uzonna
This study shows PTX3 suppresses Th17 responses and increases susceptibility to Leishmania major infection by inhibiting IL-17A production and Th17-specific transcription factors.
bioRxiv · Mar 21, 2019Immunology