Antiviral State of CD1c+ cDC contributes to Increased Maturation and Activation of Cytotoxic Natural Killer cells in Sjogrens Syndrome
I. Sanchez Cerrillo, M. Calvet Mirabent, A. Triguero Martinez, D. Calzada Fraile, C. Delgado Alfaro, M. Valdivia, M. ramirez-Huesca, E. Vazquez de Luis, A. Benguria Filippini, R. Moreno Vellisca, M. M. Adrados, H. de la Fuente, I. Tsukalov, E. Roy Vallejo, A. Ramiro, , E. Martin-Gayo
The paper identifies CD1c+ cDCs in pSS patients that enhance NK cell activation through antiviral IFN signatures and ligands for NK receptors, contributing to disease pathology.
bioRxiv · Mar 13, 2022 · PreprintImmunology