FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-cadherin
K. Kizhatil, G. Clark, D. Sunderland, A. Bhandari, L. Horbal, R. Balasubramanian, S. John
This study shows that FYN phosphorylates VE-cadherin in Schlemm's canal endothelial cells, increasing AJ permeability and reducing aqueous humor outflow resistance under elevated IOP.
bioRxiv · Sep 4, 2023 · PreprintCell Biology