HIV-1 Vif protein is stabilized by AKT-mediated phosphorylation to enhance APOBEC3G degradation
R. Raja, C. Wang, A. C. Banerjea
This study identifies AKT-mediated phosphorylation of HIV-1 Vif at T20 as a mechanism to stabilize Vif and enhance APOBEC3G degradation, revealing a complex interplay between AKT, Vif, and MDM2 in HIV-1 pathogenesis.
bioRxiv · Sep 28, 2021 · PreprintCell Biology