Author

A. C. Dommer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Approach:deep learning· 2 Organism:human· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

L. Casalino· 4 shared R. E. Amaro· 4 shared Z. Gaieb· 4 shared E. P. Barros· 3 shared A. Bogetti· 1 shared A. Brace· 1 shared A. J. Pak· 1 shared A. M. Harbison· 1 shared

Activity by Year

2020-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersBiophysics

L. Casalino

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

AI-Driven Multiscale Simulations Illuminate Mechanisms of SARS-CoV-2 Spike Dynamics

L. Casalino, A. C. Dommer, Z. Gaieb, E. P. Barros, T. Sztain, S.-H. Ahn, A. Trifan, A. Brace, H. Ma, H. Lee, M. Turilli, A. Bogetti, S. Khalid, L. Chong, C. Simmerling, , R. E. Amaro

This paper develops an AI-driven workflow to simulate SARS-CoV-2 spike protein dynamics, revealing glycan shield structure, spike glycans' role in infectivity, and spike-ACE2 interactions.

bioRxiv · Nov 19, 2020Biophysics

A Multiscale Coarse-grained Model of the SARS-CoV-2 Virion

A. Yu, A. J. Pak, P. He, V. Monje-Galvan, L. Casalino, Z. Gaieb, A. C. Dommer, R. E. Amaro, G. A. Voth

This paper develops a multiscale coarse-grained model of the SARS-CoV-2 virion using structural data and all-atom simulations to enable large-scale viral process simulations.

bioRxiv · Oct 2, 2020Biophysics

The flexibility of ACE2 in the context of SARS-CoV-2 infection

E. P. Barros, L. Casalino, Z. Gaieb, A. C. Dommer, Y. Wang, L. Fallon, L. Raguette, K. Belfon, C. L. Simmerling, R. E. Amaro

This paper uses molecular dynamics simulations to study ACE2 flexibility in SARS-CoV-2 infection, finding structural dynamics that may aid viral entry and therapeutic design.

bioRxiv · Sep 16, 2020Biophysics

Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike Protein

L. Casalino, Z. Gaieb, J. Goldsmith, C. K. Hjorth, A. C. Dommer, A. M. Harbison, C. A. Fogarty, E. P. Barros, B. C. Taylor, J. S. McLellan, E. Fadda, R. E. Amaro

This study reveals the structural role of glycans in modulating SARS-CoV-2 spike protein conformational dynamics and ACE2 binding through molecular simulations and experiments.

bioRxiv · Jun 11, 2020Biophysics