Author

A. M. Harbison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8

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Research Focus:protein folding & dynamics· 7 Organism:human· 4 Approach:deep learning· 3 Approach:mechanistic / dynamical model· 3 Assay:protein structure· 3 Assay:structural biology· 3 Approach:biophysical modeling· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

E. Fadda· 8 shared C. A. Fogarty· 6 shared A. Satheesan· 2 shared C. M. Ives· 2 shared A. C. Dommer· 1 shared A. Meller· 1 shared A. R. Dugdale· 1 shared B. C. Taylor· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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8 shared papersBiophysics

E. Fadda

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Author profile →

8 papers

Recent·Most cited

Restoring Protein Glycosylation with GlycoShape

C. M. Ives, O. Singh, S. D'Andrea, C. A. Fogarty, A. M. Harbison, A. Satheesan, B. Tropea, E. Fadda

The paper introduces GlycoShape, an open-access database and tool to restore glycosylation to protein structures using molecular dynamics simulations and public structural data.

Nature Methods · Oct 14, 2024Peer-reviewedBiophysics

GotGlycans: Role of N343 Glycosylation on the SARS-CoV-2 S RBD Structure and Co-Receptor Binding Across Variants of Concern

C. M. Ives, L. Nguyen, C. A. Fogarty, A. M. Harbison, Y. Durocher, J. S. Klassen, e. fadda

This study investigates how N343 glycosylation affects the structure and co-receptor binding of the SARS-CoV-2 S RBD across variants of concern using molecular dynamics simulations.

bioRxiv · Dec 5, 2023Biophysics

Fine-tuning the Spike: Role of the nature and topology of the glycan shield in the structure and dynamics of SARS-CoV-2 S

A. M. Harbison, C. A. Fogarty, T. K. Phung, A. Satheesan, B. L. Schulz, E. Fadda

This study uses molecular dynamics simulations to show how specific glycosylation sites on SARS-CoV-2 spike protein affect RBD stability and infectivity.

bioRxiv · Apr 1, 2021Biophysics

SARS-CoV-2 Simulations Go Exascale to Capture Spike Opening and Reveal Cryptic Pockets Across the Proteome

M. I. Zimmerman, J. R. Porter, M. D. Ward, S. Singh, N. Vithani, A. Meller, U. L. Mallimadugula, C. E. Kuhn, J. H. Borowsky, R. P. Wiewiora, M. F. D. Hurley, A. M. Harbison, C. A. Fogarty, J. E. Coffland, E. Fadda, , G. R. Bowman

The paper uses exascale simulations to study SARS-CoV-2 protein dynamics, revealing cryptic epitopes and conformational changes that inform antiviral target design.

bioRxiv · Jun 27, 2020 · PreprintBiophysics

Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike Protein

L. Casalino, Z. Gaieb, J. Goldsmith, C. K. Hjorth, A. C. Dommer, A. M. Harbison, C. A. Fogarty, E. P. Barros, B. C. Taylor, J. S. McLellan, E. Fadda, R. E. Amaro

This study reveals the structural role of glycans in modulating SARS-CoV-2 spike protein conformational dynamics and ACE2 binding through molecular simulations and experiments.

bioRxiv · Jun 11, 2020Biophysics

How and why plants and humans N-glycans are different: Insight from molecular dynamics into the "glycoblocks" architecture of complex carbohydrates

C. A. Fogarty, A. M. Harbison, A. R. Dugdale, E. Fadda

This study uses molecular dynamics to analyze N-glycan structures in plants and invertebrates, comparing them to human glycans to understand structural differences and their immunogenic effects.

bioRxiv · May 22, 2020Biophysics

An atomistic perspective on ADCC quenching by core-fucosylation of IgG1 Fc N-glycans from enhanced sampling molecular dynamics

A. M. Harbison, E. Fadda

This study uses enhanced sampling molecular dynamics to show how core-fucosylation of IgG1 Fc N-glycans reduces ADCC by altering Fc conformation and blocking FcγR binding.

bioRxiv · Jul 15, 2019Biophysics

Sequence-to-structure dependence of isolated IgG Fc complex biantennary N-glycans: A molecular dynamics study

A. M. Harbison, L. Brosnan, K. Fenlon, E. Fadda

This study uses molecular dynamics simulations to investigate how the sequence of biantennary N-glycans affects their structure and dynamics, revealing that galactosylation significantly alters conformational equilibrium.

bioRxiv · Aug 14, 2018Biophysics