Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity.
R. Di Martino, A. Capalbo, L. Sticco, A. Varavallo, V. Kunnathully, V. De Luca, N. R. Iyengar, M. Lo Monte, P. Henklein, J. Cancino, A. Luini
The paper identifies a mechanism called ARTG that regulates basolateral cargo export from the TGN via GPRC5A, PLCβ3, and PKD signaling, and shows its role in epithelial cell polarity.
bioRxiv · May 26, 2020 · PreprintCell Biology