A Thioredoxin reductive mechanism balances the oxidative protein import pathway in the intermembrane space of mitochondria
M. Cardenas-Rodriguez, P. Manganas, E. Kallergi, R. Edwards, A. Chatzi, E. Lacko, K. Tokatlidis
This study identifies the cytosolic thioredoxin system's role in balancing mitochondrial oxidative folding via its localization in the intermembrane space and its regulation of Mia40 redox state.
bioRxiv · Jun 22, 2021 · PreprintBiochemistry