CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells
A. Conery, A. Bommi-Reddy, S. Park-Chouinard, D. N. Mayhew, E. Terzo, A. Hingway, M. J. Steinbaugh, J. E. Wilson, R. J. Sims
This study shows that inhibiting CREBBP/EP300 acetyltransferase suppresses ER+ breast cancer growth by disrupting FOXA1-bound enhancers, offering a new therapeutic strategy.
bioRxiv · Dec 26, 2021Cancer Biology