Broad gene expression throughout the mouse and marmoset brain after intravenous delivery of engineered AAV capsids
N. C. Flytzanis, N. Goeden, D. Goertsen, A. Cummins, J. Pickel, V. Gradinaru
The paper identifies AAV capsid variants that target the brain with high specificity and avoid liver expression in mice and marmoset non-human primates.
bioRxiv · Jun 16, 2020Bioengineering