Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease
A. D'Oliviera, X. Dai, S. Mottaghinia, S. Olson, E. P. Geissler, L. Etienne, Y. Zhang, J. S. Mugridge
This study identifies TRMT1 as a target of SARS-CoV-2 Mpro, showing cleavage disrupts its tRNA methyltransferase activity and impacts host translation and oxidative stress response.
bioRxiv · Feb 20, 2023Biochemistry