Y. Zhang

Benchmarking foundation models for resting-state functional magnetic resonance imaging time series in cognitive aging research

This study benchmarks foundation models for resting-state fMRI time series in cognitive aging, finding mixed results on their utility for cognitive assessment and prediction.

Serotonin Reuptake Inhibition Reduces NMDAR-Associated Reward Liability Without Compromising Rapid Antidepressant Efficacy

This study shows that combining serotonin reuptake inhibition with NMDAR antagonism reduces reward-related effects while maintaining rapid antidepressant efficacy.

A PTN-Rich MSC Subtype Promotes Cartilage Repair in End-Stage Knee Osteoarthritis

The paper identifies a PTN-rich MSC subtype that enhances cartilage repair in KOA by modulating key inflammatory and repair pathways.

π-SPECFormer: A Mass Spectrometry-based Foundation Model for Decoding the Dark Proteome

This paper introduces π-SPECFormer, a foundation model for mass spectrometry-based proteomics that decodes the dark proteome by pre-training on unannotated spectra and outperforms baselines in peptide sequencing and modification detection.

A trustworthy semantic knowledge network linking data-driven cell phenotypes to diseases and drugs

The paper develops NLM-CKN, a semantic knowledge network linking cell phenotypes to diseases and drugs using integrated data from 88 datasets.

Leptin Receptor+ cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14

The paper identifies LepR+ cells as a niche for thrombopoiesis by producing CXCL14, which regulates lipid metabolism and terminal differentiation in megakaryocytes.

Phenotypic screens identify biologic regulators of nanoparticle uptake in diffuse midline glioma

The paper identifies biologic regulators of nanoparticle uptake in diffuse midline glioma using CRISPR screens and functional assays, finding CTNNB1 and pathway members as key modulators.

Single-atom inhibition of oncogenic drivers through cysteine coordination

This paper introduces single-atom inhibition using gold to target oncogenic proteins by coordinating with cysteine residues, showing efficacy in suppressing cancer cell growth and tumor progression.

Microenvironment T-Type calcium channels regulate neuronal and glial processes to promote glioblastoma growth

This study shows that microenvironment T-type calcium channels promote glioblastoma growth by regulating neuronal and glial processes, and that blocking these channels with mibefradil enhances the effectiveness of standard therapies.

Vascular transcriptional and metabolic changes precede progressive intra-renal microvascular rarefaction in autosomal dominant polycystic kidney disease

This study identifies early vascular transcriptional and metabolic changes preceding microvascular rarefaction in ADPKD using mouse models and human cohorts.

Mass mortality associated with Carpione Rhabdovirus in golden pompano (Trachinotus ovatus) in China: First report

This study reports the first natural infection of Carpione Rhabdovirus in golden pompano fish in China, associated with high mortality and characterized by viral morphology and genetic analysis.

Synergistic Multi-Enzyme Cascades Assembled on Modular Protein Scaffolds for Efficient PET Biorecycling

This paper develops a modular protein scaffold system to assemble multiple enzymes for efficient PET biorecycling, achieving higher conversion rates than previous systems.

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

ILC2s navigate tissue redistribution during infection using stage-specific S1P receptors

This study shows that ILC2s use different S1P receptors at distinct stages to migrate during infection, highlighting a shared vascular network for lymphocyte movement.

Human metapneumovirus SH protein promotes JAK1 degradation to impair host IL-6 signaling

This paper identifies the HMPV SH protein as a factor that inhibits IL-6 signaling by promoting JAK1 proteasomal degradation, contributing to immune evasion.

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution

This study integrates spatial transcriptomics and single-cell data from gastric cancer samples to reveal tumor ecosystem dynamics, evolutionary trajectories, and immune microenvironment features.

hESCs-derived organoids achieve liver zonation by LSEC modulation

This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.

Protein S-glutathionylation confers cell resistance to ferroptosis

This study shows that protein S-glutathionylation protects cells from ferroptosis by maintaining ARF6 function and reducing labile iron pools.

The tricellular junction protein ILDR2 in glomerulopathies: insights and implications

This study investigates ILDR2's role in glomerulopathies, finding it upregulated in disease models and suggesting a protective effect against glomerular damage.

An shRNA screen in primary human beta cells identifies the serotonin 1F receptor as a negative regulator of survival during transplant

The paper identifies the serotonin 1F receptor as a negative regulator of human beta cell survival during transplant and demonstrates a small molecule antagonist that improves glycemia in islet transplants.

Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)

The paper reports high-resolution cryo-EM structures of human PCC and MCC, revealing substrate binding modes and biotin coordination mechanisms.

Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis

TLR5 deficiency is linked to pulmonary fibrosis due to its role in preventing microbial dysbiosis following lung injury.

The Unexpected Membrane Targeting of Marchantia Short PIN Auxin Exporters Illuminates Sequence Determinants and Evolutionary Significance

This study identifies the sequence determinant for PM localization in short PINs and explains the evolutionary shift from PM- to ER-localized PINs in land plants.

The enhancement of electricity generation using cellulose based on ternary microbial consortium

This paper demonstrates that a ternary microbial consortium enhances electricity generation from cellulose by synergistically converting it to acetate and using riboflavin as an electron shuttle.

Measuring single-cell density with high throughput enables dynamic profiling of immune cell and drug response from patient samples

The paper develops a high-throughput method to measure single-cell density and applies it to study immune cell states and drug response in patient samples.

Measuring PETase enzyme kinetics by single-molecule microscopy

This paper develops a single-molecule microscopy assay to measure PETase enzyme kinetics, revealing distinct binding dynamics between wild-type and a hyperactive mutant.

Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors

This study identifies WSB2 as a regulator of mitochondrial apoptosis and shows that targeting the WSB2-NOXA axis enhances sensitivity to BCL-2 inhibitors in cancer cells.

Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions

The paper examines how divergence in intrinsically disordered regions of a eukaryotic transcription factor affects its co-TF dependence across species.