Author

A. D. Sharrocks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Rogerson· 2 shared E. Britton· 2 shared S. Ogden· 2 shared the OCCAMs consortium· 2 shared Y. Ang· 2 shared J. Bruce· 1 shared K. Carys· 1 shared N. Hanley· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

C. Rogerson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Widespread reorganisation of the regulatory chromatin landscape facilitates resistance to inhibition of oncogenic ERBB2 signalling.

S. Ogden, K. Carys, J. Bruce, the OCCAMs consortium, A. D. Sharrocks

The paper shows that ERBB2 inhibition in OAC cells leads to chromatin remodelling and rewiring of gene regulatory networks, enabling resistance through metabolic shifts and transcriptional regulators.

bioRxiv · Apr 29, 2021 · PreprintCancer Biology

Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to Oesophageal Adenocarcinoma

C. Rogerson, S. Ogden, E. Britton, the OCCAMS consortium, Y. Ang, A. D. Sharrocks

The paper identifies a cell cycle gene expression signature in Oesophageal Adenocarcinoma (OAC) and shows KLF5's repurposing to regulate cell cycle genes during progression from Barrett's oesophagus to OAC.

bioRxiv · Feb 10, 2020Cancer Biology

Identification of a primitive intestinal transcription factor network shared between oesophageal adenocarcinoma and its pre-cancerous precursor state

C. Rogerson, E. Britton, S. Withey, N. Hanley, Y. Ang, A. D. Sharrocks

This study identifies a primitive intestinal transcription factor network, centered on HNF4A and GATA6, that is active in oesophageal adenocarcinoma and its precursor state, Barretts oesophagus.

bioRxiv · Jul 30, 2018Cancer Biology