Author

K. Carys

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. D. Sharrocks· 1 shared J. Bruce· 1 shared S. Ogden· 1 shared the OCCAMs consortium· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperCancer Biology

A. D. Sharrocks

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1 paper

Recent·Most cited

Widespread reorganisation of the regulatory chromatin landscape facilitates resistance to inhibition of oncogenic ERBB2 signalling.

S. Ogden, K. Carys, J. Bruce, the OCCAMs consortium, A. D. Sharrocks

The paper shows that ERBB2 inhibition in OAC cells leads to chromatin remodelling and rewiring of gene regulatory networks, enabling resistance through metabolic shifts and transcriptional regulators.

bioRxiv · Apr 29, 2021 · PreprintCancer Biology