the OCCAMs consortium

Oncogenic ERRB2 signals through the AP-1 transcription factor to control mesenchymal-like properties of oesophageal adenocarcinoma

This study identifies AP-1 as a key transcription factor mediating ERBB2-driven mesenchymal-like properties in oesophageal adenocarcinoma through integrated phosphoproteomics, open chromatin profiling, and transcriptome analysis.

eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways

The paper identifies enhancer RNAs in oesophageal adenocarcinoma using RNA-seq and open chromatin maps, revealing new deregulated pathways and their clinical relevance.

Widespread reorganisation of the regulatory chromatin landscape facilitates resistance to inhibition of oncogenic ERBB2 signalling.

The paper shows that ERBB2 inhibition in OAC cells leads to chromatin remodelling and rewiring of gene regulatory networks, enabling resistance through metabolic shifts and transcriptional regulators.

Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to Oesophageal Adenocarcinoma

The paper identifies a cell cycle gene expression signature in Oesophageal Adenocarcinoma (OAC) and shows KLF5's repurposing to regulate cell cycle genes during progression from Barrett's oesophagus to OAC.