GATA2 Induces a Stem Cell-Like Transcriptional Program in Macrophages that Promotes Atherogenesis.
Amena Aktar, Angela M. Vrieze, Kiera Telesnicki, Paisley Cox‐Duvall, Matthew Arbolino, Rodney P. DeKoter, A. Dave Nagpal, Bryan Heit
This study shows that GATA2 upregulation in macrophages promotes atherogenesis by inducing a stem cell-like transcriptional program that impairs cholesterol efflux and phagocytosis.
bioRxiv · Jul 18, 2025 · PreprintImmunology