Functional and structural characterization of allosteric activation of Phospholipase Cϵ by Rap1A
M. Sieng, A. F. Selvia, E. E. Garland-Kuntz, J. B. Hopkins, I. J. Fisher, A. T. Marti, A. Lyon
This study shows Rap1A allosterically activates PLCε by stabilizing interactions between the RA2 domain and the PLC core, confirmed through biochemical and structural analyses.
bioRxiv · Jul 10, 2020Biochemistry