Mesenchymal stem cell culture within perfusion bioreactors incorporating 3D-printed scaffolds enables improved extracellular vesicle yield with preserved bioactivity
S. M. Kronstadt, D. B. Patel, L. J. Born, D. Levy, M. J. Lerman, B. Mahadik, S. T. McLoughlin, A. Fasuyi, L. Fowlkes, L. Hoorens van Heyningen, A. Aranda, S. N. Abadchi, K.-H. Chang, A. T. W. Hsu, S. Bengali, , S. M. Jay
This study shows that culturing mesenchymal stem cells in 3D-printed scaffold perfusion bioreactors increases extracellular vesicle production and improves wound healing in diabetic mice.
Advanced Healthcare Materials · Apr 2, 2023Peer-reviewedBioengineering