A. G. Holt

The prevalence of dementia in humans could be the result of a functional adaptation

This study suggests that high mitochondrial DNA copy number in neurons may be a functional adaptation that delays cognitive decline until after reproductive age, potentially explaining the prevalence of dementia in older humans.

The significance of mitochondrial DNA half-life to the lifespan of post-mitotic cells

This study models how mtDNA half-life affects mtDNA competition and survival in post-mitotic cells, finding that increasing half-life mitigates the replicative advantage of deletion mutants.