Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective againstOmicron
D. Bottero, E. Rudi, P. M. Aispuro, M. E. Zurita, M. E. Gaillard, M. M. G. L. Ledesma, J. Malito, M. Stuible, N. M. Ambrosis, Y. Durocher, A. Gamarnik, A. Wigdorovitz, D. Hozbor
This study evaluates the effectiveness of heterologous booster vaccines against Omicron BA.1 using a mouse model, showing that mRNA-based vaccines outperform vector-based ones, while heterologous boosters improve immune responses.
bioRxiv · Oct 5, 2023Immunology