Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
M. Berquez, Z. Chen, B. P. Festa, P. Krohn, S. A. Keller, S. Parolo, M. Korzinkin, A. Gaponova, E. Laczko, E. Domenici, O. Devuyst, A. Luciani
This study shows that lysosomal cystine export via CTNS regulates mTORC1 signaling, influencing kidney epithelial cell fate and function in cystinosis.
bioRxiv · Aug 28, 2022Cell Biology