WWOX promotes osteosarcoma development via upregulation of Myc
R. Akkawi, O. Hidmi, A. Haj Yahia, J. Monin, J. Diment, Y. Drier, G. S. Stein, R. I. Aqeilan
This study shows that WWOX deletion in combination with Trp53 deletion promotes osteosarcoma by upregulating Myc and its targets, with MCM7 as a key mediator.
bioRxiv · Mar 14, 2023Cancer Biology