Escape mutations circumvent a tradeoff between resistance to beta-lactams and a beta-lactamase inhibitor
D. Russ, F. Glaser, E. Shaer Tamar, I. Yelin, C. Zampaloni, A. Haldimann, R. Kishony
The paper identifies escape mutations in the ampC beta-lactamase gene of E. coli that allow resistance to beta-lactams while maintaining resistance to inhibitors, showing drug-specific patterns.
bioRxiv · Aug 9, 2019Microbiology