Hypertrophied human adipocyte spheroids as in vitro model of weight gain and adipose tissue dysfunction
A. Ioannidou, S. Alatar, M. Ahlander, A. Hornell, R. M. Fisher, C. E. Hagberg
This study develops a 3D culture protocol for human adipocytes that mimics in vivo adipogenesis and induces adipocyte hypertrophy, leading to dysfunction features like altered adipokine secretion and impaired lipolysis.
bioRxiv · Jan 6, 2021Cell Biology