Reprogramming the antigen specificity of B cells using genome-editing technologies
J. E. Voss, A. Gonzalez-Martin, R. Andrabi, R. P. Fuller, B. Murrell, L. E. McCoy, K. Porter, D. Huang, W. Li, D. Sok, K. Le, B. Briney, M. Chateau, G. Rogers, L. Hangartner, , D. Burton
This study reprograms B cells to express HIV-specific BCRs by editing immunoglobulin genes with CRISPR-Cas9, enabling improved anti-HIV neutralizing activity.
bioRxiv · Oct 29, 2018Immunology