L. E. McCoy

Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

Attenuated humoral responses in HIV infection after SARS-CoV-2 vaccination are linked to global B cell defects and cellular immune profiles

This study examines humoral and cellular immune responses to SARS-CoV-2 vaccination in HIV-infected individuals, finding reduced antibody responses and B cell dysfunction, but robust T cell responses.

SARS-CoV-2-specific memory B cells can persist in the elderly despite loss of neutralising antibodies

Circulating class-switched spike and RBD-specific memory B cells can outlast detectable neutralising antibodies but are functionally constrained in the elderly.

Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2

This study characterizes the B.1.1.7 and Pangolin coronavirus spike proteins, revealing how NTD mutations enhance viral entry and provide insights into SARS-CoV-2 evolution.

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

This study examines SARS-CoV-2-specific immune responses in people living with HIV on ART, finding comparable antibody and T cell responses to HIV-negative individuals, with T cell magnitude linked to CD4 T cell pool size and CD4:CD8 ratio.

Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

This study examines how mutations in the B.1.1.7 variant of SARS-CoV-2 affect neutralization by monoclonal antibodies targeting non-RBD epitopes.

The impact of Spike mutations on SARS-CoV-2 neutralization

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

The paper identifies monoclonal antibodies from rabbits that bind an epitope overlapping the N332 glycan supersite but not the glycan hole, suggesting strain-specific responses may interfere with broadly neutralizing antibodies.

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

This study shows that immunization with B41 and BG505 SOSIP trimer immunogens in rabbits induces distinct autologous neutralizing antibody lineages targeting overlapping glycan hole epitopes, but broadening reactivity remains challenging.

Reprogramming the antigen specificity of B cells using genome-editing technologies

This study reprograms B cells to express HIV-specific BCRs by editing immunoglobulin genes with CRISPR-Cas9, enabling improved anti-HIV neutralizing activity.