D. Burton

Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire

This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.

The N-terminus of Plasmodium falciparum Circumsporozoite Protein Contains Three Non-Overlapping Murine B-cell Epitope Regions

This study identifies three non-overlapping B-cell epitope regions in the N-terminus of Plasmodium falciparum CSP using monoclonal antibodies from immunized mice.

B cell repertoire sequencing of HIV-1 pediatric elite-neutralizers identifies multiple broadly neutralizing antibody clonotypes

This study identifies multiple broadly neutralizing antibody clonotypes in HIV-1 infected pediatric twins using BCR sequencing, showing ongoing development in one twin but not the other.

Broad-Spectrum Heavily Mutated Monoclonal Antibody Isolated from COVID-19 Convalescent Vaccinee with Capacity to Neutralize SARS-CoV2 Variants Ranging from B.1 to BQ.1.1

The paper isolates and characterizes Acovimab, a broadly neutralizing monoclonal antibody against SARS-CoV-2 variants, showing potent neutralization against most variants except XBB.1.5 and synergistic activity with Sotrovimab.

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple epitopes

The paper identifies two broadly neutralizing antibodies against coronaviruses by screening B cell repertoires, showing they target different epitopes and offer protection against variants.

The diversity of the glycan shield of sarbecoviruses closely related to SARS-CoV-2

This study compares the glycan shields of sarbecoviruses to understand how sequence variations affect their structure and potential for antibody neutralization.

A broad and potent neutralization epitope in SARS-related coronaviruses

The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

This study engineers SARS-CoV-2 neutralizing antibodies through directed evolution to enhance their potency and reduce viral escape.

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit.

This paper identifies a conserved neutralizing epitope on the spike S2 subunit of sarbecoviruses, demonstrating cross-neutralization against multiple variants and a bat coronavirus.

Broadening a SARS-CoV-1 neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

This paper describes engineering a SARS-CoV-1 neutralizing antibody to effectively neutralize SARS-CoV-2 through directed evolution and affinity maturation.

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

This study maps antibody responses to HIV-1 envelope trimers in non-human primates, identifying strain-specific and conserved epitopes recognized by vaccine-induced antibodies.

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

This study maps polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines and identifies epitopes associated with neutralization breadth.

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

The paper identifies monoclonal antibodies from rabbits that bind an epitope overlapping the N332 glycan supersite but not the glycan hole, suggesting strain-specific responses may interfere with broadly neutralizing antibodies.

Reprogramming the antigen specificity of B cells using genome-editing technologies

This study reprograms B cells to express HIV-specific BCRs by editing immunoglobulin genes with CRISPR-Cas9, enabling improved anti-HIV neutralizing activity.