An antisense oligonucleotide leads to suppressed transcriptional elongation of Hdac2 and long-term memory enhancement
S. Poplawski, K. A. Garbett, R. L. McMahan, H. B. Kordasiewicz, H. Zhao, A. J. Kennedy, S. B. Goleva, T. H. Sanders, T. Motley, E. E. Swayze, D. J. Ecker, D. Sweatt, T. P. Michael, C. B. Greer
This study shows that an antisense oligonucleotide reduces Hdac2 mRNA and enhances memory in mice by inhibiting RNA polymerase II elongation.
bioRxiv · Aug 31, 2019Pharmacology & Toxicology