Author

H. B. Kordasiewicz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. G. Reidenbach· 1 shared A. J. Kennedy· 1 shared A. J. Leed· 1 shared C. B. Greer· 1 shared D. J. Ecker· 1 shared D. Sweatt· 1 shared E. E. Swayze· 1 shared E. V. Minikel· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. G. Reidenbach

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Author profile →

2 papers

Recent·Most cited

Characterization of the prion protein binding properties of antisense oligonucleotides

A. G. Reidenbach, E. V. Minikel, H. T. Zhao, S. G. Guzman, A. J. Leed, M. F. Mesleh, H. B. Kordasiewicz, S. L. Schreiber, S. M. Vallabh

This study examines the binding and antiprion properties of antisense oligonucleotides (ASOs) targeting prion protein (PrP), finding that sequence-independent binding and aggregation occur, but only PrP-lowering ASOs are effective in vivo.

bioRxiv · Nov 7, 2019Biochemistry

An antisense oligonucleotide leads to suppressed transcriptional elongation of Hdac2 and long-term memory enhancement

S. Poplawski, K. A. Garbett, R. L. McMahan, H. B. Kordasiewicz, H. Zhao, A. J. Kennedy, S. B. Goleva, T. H. Sanders, T. Motley, E. E. Swayze, D. J. Ecker, D. Sweatt, T. P. Michael, C. B. Greer

This study shows that an antisense oligonucleotide reduces Hdac2 mRNA and enhances memory in mice by inhibiting RNA polymerase II elongation.

bioRxiv · Aug 31, 2019Pharmacology & Toxicology