Author

A. J. McNamara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1

Frequent Co-Authors

P. Danthi· 3 shared A. D. Brooks· 1 shared A. T. Abad· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 2 mutual co-author links

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3 shared papersMicrobiology

P. Danthi

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3 papers

Recent·Most cited

Proteasome activity is required for reovirus entry into cells

A. T. Abad, A. J. McNamara, P. Danthi

This study shows that proteasome activity is required for reovirus entry, as proteasome inhibition blocks infection after ISVP formation but before transcriptional activation.

bioRxiv · May 10, 2023Microbiology

The reovirus σ3 protein inhibits NF-κB-dependent antiviral signaling

A. J. McNamara, A. D. Brooks, P. Danthi

This paper identifies a second mechanism by which reovirus inhibits NF-κB-dependent antiviral signaling through the σ3 protein, which reduces expression of NF-κB target genes without affecting IKK levels or activity.

bioRxiv · Oct 5, 2021Microbiology

Loss of IKK subunits limits NF-κB signaling in reovirus infected cells

A. J. McNamara, P. Danthi

This study shows that reovirus infection inhibits NF-κB signaling by reducing IKK complex components, thereby blocking gene expression and promoting viral replication.

bioRxiv · Nov 15, 2019Microbiology