Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function.
S. Khani, H. Topel, A. Josephrajan, B. D. M. Larsen, A. R. A. d. A. Tavanez, M. J. Gaudry, P. Leyendecker, N. Stanic, I. Gaziano, N. R. Hansmeier, E. Schmidt, P. Klemm, L.-M. Vagliano, C. A. Engelhard, S. Nielsen, , J.-W. Kornfeld
The paper identifies a cold-inducible truncated Adcy3 mRNA isoform, Adcy3-at, which acts as a rheostat to regulate brown fat function by limiting cAMP activity during obesity.
bioRxiv · Aug 1, 2022Cell Biology