A. Pfeifer

Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

Efficient targeting of heart lesions with cardiac myofibroblasts: Combined gene and cell therapy enhanced by magnetic steering

The paper develops a method to target cardiac scars using genetically modified myofibroblasts guided by magnetic steering, showing improved engraftment and reduced ventricular tachycardia.

Porcine and human aortic valve endothelial and interstitial cell isolation and characterization

This study isolates and characterizes human and porcine aortic valve endothelial and interstitial cells, comparing their gene expression and calcification responses.

Aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk

This study identifies miR-145-5p as a key regulator of aortic valve calcification through EV-mediated crosstalk, showing it suppresses ZEB2 to enhance ALPL expression and promote calcification in valvular interstitial cells.

AdipoQ - a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro

AdipoQ quantifies adipocyte morphology and function in tissues and in vitro using an open-source ImageJ plugin for automated analysis.

GPR183 targets lung-resident CD301b+ conventional dendritic cells type 2 to a subtissular TSLP-TSLP receptor-mediated survival niche within the adventitial cuff

This study identifies GPR183 as a key receptor guiding CD301b+ cDC2 to a TSLP-dependent survival niche in the lung adventitial cuff.

Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function.

The paper identifies a cold-inducible truncated Adcy3 mRNA isoform, Adcy3-at, which acts as a rheostat to regulate brown fat function by limiting cAMP activity during obesity.