Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signaling networks using SILAC-based phosphoproteomics
D. P. Byrne, C. J. Clarke, P. Brownridge, A. Kalyuzhnyy, S. Perkins, A. Campbell, D. Mason, A. R. Jones, P. A. Eyers, C. E. Eyers
This study uses centrinone and SILAC-based phosphoproteomics to identify PLK4 substrates and reveal a network of PLK4-regulated phosphorylation motifs in human cells.
bioRxiv · May 22, 2020Biochemistry