Biochemical characterization of naturally occurring mutations in SARS-CoV-2 RNA-dependent RNA polymerase
M. Danda, A. Klimesova, K. Kuskova, A. Dostalkova, A. Pagacova, J. Prchal, M. Kapisheva, T. Ruml, M. Rumlova
This study examines the phenotypic effects of mutations in SARS-CoV-2 RdRp subunits using biochemical assays, finding that some mutations alter enzyme stability, complex assembly, and activity, with implications for antiviral resistance.
bioRxiv · Feb 24, 2024Biochemistry